Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1

Author:

Xie Linan1,Xiao Dongliang1,Wang Xiaojing23,Wang Chen1,Bai Jing14,Yue Qun1,Yue Haitao5,Li Ye26,Molnár István2ORCID,Xu Yuquan1,Zhang Liwen1ORCID

Affiliation:

1. Biotechnology Research Institute, The Chinese Academy of Agricultural Sciences, Beijing, People’s Republic of China

2. Southwest Center for Natural Products Research, University of Arizona, Tucson, Arizona, USA

3. Microbial Pharmacology Laboratory, Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China

4. School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province, People’s Republic of China

5. Department of Biology and Biotechnology, Xinjiang University, Urumqi, People’s Republic of China

6. National Engineering Lab for Cereal Fermentation Technology, Jiangnan University, Wuxi, People’s Republic of China

Abstract

Sulfation is an expedient strategy to increase the solubility, bioavailability, and bioactivity of nutraceuticals and clinically important drugs. However, chemical or biological synthesis of sulfoconjugates is challenging.

Funder

Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary

HHS | National Institutes of Health

USDA | National Institute of Food and Agriculture

National Natural Science Foundation of China

Joint Genome Institute

MOST | National Key Research and Development Program of China

MOA | CAFS | Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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