Immunization of Rabbits with a QuadrivalentShigellaBioconjugate Vaccine Induces Functional Antibodies Reactive withShigellaIsolates from Kenya

Abstract

Diarrheal diseases are the third leading cause of death globally, disproportionally affecting low- to middle-income countries like Kenya, withShigellaspecies being the leading cause of bacterial diarrhea, especially in children. The low infectious dose and high antibiotic resistance levels complicate treatment, leading to long-term sequelae that necessitate control measures such as vaccines to reduce morbidity and mortality rates, especially among children under 5 years of age.