Gastric Non-Helicobacter pylori Urease-Positive Staphylococcus epidermidis and Streptococcus salivarius Isolated from Humans Have Contrasting Effects on H. pylori-Associated Gastric Pathology and Host Immune Responses in a Murine Model of Gastric Cancer

Author:

Shen Zeli1,Dzink-Fox JoAnn1,Feng Yan1,Muthupalani Sureshkumar1,Mannion Anthony J.1ORCID,Sheh Alexander1,Whary Mark T.1,Holcombe Hilda R.1,Piazuelo Blanca M.2,Bravo Luis E.3,Josenhans Christine4,Suerbaum Sebastian4,Wilson Keith T.2,Peek Richard M.2,Wang Timothy C.5,Fox James G.1ORCID

Affiliation:

1. Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

2. Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. Department of Pathology, Universidad del Valle, Cali, Colombia

4. Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Ludwig Maximilians University, Munich, Germany

5. Division of Gastroenterology and Irvine Cancer Research Center, Columbia University, New York, New York, USA

Abstract

Chronic infection with H. pylori is the main cause of gastric cancer, which is a global health problem. In two Colombian populations with high levels of H. pylori prevalence, the regional gastric cancer rates are considerably different.

Funder

亥姆霍兹联合会致力 | Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München

Deutsches Zentrum für Infektionsforschung

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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