PARIS and SPARTA: Finding the Achilles’ Heel of SARS-CoV-2

Author:

Simon Viviana12345,Kota Vamsi6,Bloomquist Ryan F.7,Hanley Hannah B.8,Forgacs David8,Pahwa Savita9,Pallikkuth Suresh9,Miller Loren G.1011,Schaenman Joanna10,Yeaman Michael R.1011,Manthei David12,Wolf Joshua13ORCID,Gaur Aditya H.13,Estepp Jeremie H.13,Srivastava Komal1,Carreño Juan Manuel1,Cuevas Frans1,Ellebedy Ali H.141516,Gordon Aubree12,Valdez Riccardo17,Cobey Sarah18,Reed Elaine F.19,Kolhe Ravindra2067,Thomas Paul G.13,Schultz-Cherry Stacey13ORCID,Ross Ted M.821ORCID,Krammer Florian145ORCID,

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

4. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Center for Vaccine Research and Pandemic Preparedness (C-VARPP), Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

7. Department of Restorative Sciences, Dental College of Georgia, Augusta University, Augusta, Georgia, USA

8. Center for Vaccine and Immunology, University of Georgia, Athens, Georgia, USA

9. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, USA

10. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

11. Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA

12. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA

13. Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee, USA

14. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

15. Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA

16. Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, Missouri, USA

17. Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA

18. Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA

19. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA

20. Department of Pathology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

21. Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA

Abstract

Determining reinfection rates and correlates of protection against SARS-CoV-2 infection induced by both natural infection and vaccination is of high significance for the prevention and control of coronavirus disease 2019 (COVID-19). Furthermore, understanding reinfections or infection after vaccination and the role immune escape plays in these scenarios will inform the need for updates of the current SARS-CoV-2 vaccines and help update guidelines suitable for the postpandemic world.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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