Affiliation:
1. Department of Global Health and Florida Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA
Abstract
Toxoplasma
infections are lifelong because of the development of the bradyzoite tissue cyst, which is effectively invisible to the immune system. Despite the important clinical consequences of this developmental pathway, the molecular basis of the switch mechanisms that control tissue cyst formation is still poorly understood. Significant changes in gene expression are associated with tissue cyst development, and ApiAP2 transcription factors are an important mechanism regulating this developmental transcriptome. However, the molecular composition of these ApiAP2 complexes and the operating principles of ApiAP2 mechanisms are not well defined. Here we establish that competing ApiAP2 transcriptional mechanisms operate to regulate this clinically important developmental pathway.
Funder
HHS | National Institutes of Health
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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