VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display-Reference-Cited by-同舟云学术

VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display

Published:2023-02-21 Issue:1 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Kingston Natalie J.¹^ORCID,Grehan Keith¹^ORCID,Snowden Joseph S.¹^ORCID,Hassall Mark²,Alzahrani Jehad¹,Paesen Guido C.³,Sherry Lee¹^ORCID,Hayward Connor¹,Roe Amy¹,Stephen Sam¹,Tomlinson Darren¹,Zeltina Antra³,Doores Katie J.⁴^ORCID,Ranson Neil A.¹^ORCID,Stacey Martin¹^ORCID,Page Mark²,Rose Nicola J.²,Bowden Thomas A.³^ORCID,Rowlands David J.¹^ORCID,Stonehouse Nicola J.¹^ORCID

Affiliation:

1. Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom

2. Division of Virology, National Institute for Biological Standards and Control (NIBSC), Hertfordshire, United Kingdom

3. Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

4. Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, United Kingdom

Abstract

The hepatitis B core protein (HBc) forms noninfectious virus-like particles, which can be modified to present a capturing molecule, allowing suitably tagged antigens to be bound on their surface. This system can be adapted and provides the foundation for a universal “bolt-on” vaccine platform (termed VelcroVax) that can be easily and rapidly modified to generate nanoparticle vaccine candidates.

Funder

HHS | NIH | OSC | Common Fund

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00568-22

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