Evaluation of Winter Ticks (Dermacentor albipictus) Collected from North American Elk (Cervus canadensis) in an Area of Chronic Wasting Disease Endemicity for Evidence of PrP CWD Amplification Using Real-Time Quaking-Induced Conversion Assay

Author:

Haley N. J.1ORCID,Henderson D. M.2,Senior K.1,Miller M.1,Donner R.1

Affiliation:

1. Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, Arizona, USA

2. CWDEvolution LLC, San Diego, California, USA

Abstract

This study reports the first finding of detectable levels of prions linked to chronic wasting disease in a tick collected from a clinically infected elk. Using the real-time quaking-induced conversion assay (RT-QuIC), “suspect” samples were also identified; these suspect ticks were more likely to have been collected from CWD-positive elk, though suspect amplification was also observed in ticks collected from CWD-negative elk.

Funder

Midwestern University

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference54 articles.

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3. Prion diseases

4. PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.)

5. ProMED-Mail. 27 September 2019. Chronic wasting disease - Sweden: leNorrbotten) moose first case. ProMED-Mail archive no. 20190927.6696895. https://promedmail.org/promed-post/?id=6696895.

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