Vibrio cholerae Sialidase-Specific Immune Responses Are Associated with Protection against Cholera

Author:

Kaisar M. Hasanul1,Bhuiyan Mohammed Saruar1,Akter Aklima1,Saleem Danial2,Iyer Anita S.34,Dash Pinki1,Hakim Al1,Chowdhury Fahima1,Khan Ashraful Islam1,Calderwood Stephen B.345,Harris Jason B.367,Ryan Edward T.348,Qadri Firdausi1,Charles Richelle C.34ORCID,Bhuiyan Taufiqur Rahman1ORCID

Affiliation:

1. Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh

2. College of Physicians and Surgeons, Columbia University, New York, New York, USA

3. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

4. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

5. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

6. Division of Global Health, Massachusetts General Hospital for Children, Boston, Massachusetts, USA

7. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA

8. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

Abstract

Cholera infection can result in severe dehydration that may lead to death within a short period of time if not treated immediately. Vaccination is an important strategy to prevent the disease.

Funder

HHS | NIH | Fogarty International Center

Robert Wood Johnson Foundation

Bill and Melinda Gates Foundation

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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