RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity-Reference-Cited by-同舟云学术

RND Pump-Mediated Efflux of Amotosalen, a Compound Used in Pathogen Inactivation Technology to Enhance Safety of Blood Transfusion Products, May Compromise Its Gram-Negative Anti-Bacterial Activity

Published:2023-04-20 Issue:2 Volume:8 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Green Alex B.¹,Chiaraviglio Lucius¹,Truelson Katherine A.¹,Zulauf Katelyn E.¹²,Cui Meng³,Zhang Zhemin⁴,Ware Matthew P.¹,Flegel Willy A.⁵^ORCID,Haspel Richard L.¹²,Yu Edward W.⁴,Kirby James E.¹²^ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

2. Harvard Medical School, Boston, Massachusetts, USA

3. Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts, USA

4. Department of Pharmacology, Case Western Reserve University Medical Center, Cleveland, Ohio, USA

5. Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health Bethesda, Maryland, USA

Abstract

Pathogen inactivation is a strategy to enhance the safety of transfused blood products. We identify the compound, amotosalen, widely used for pathogen inactivation, as a bacterial multidrug efflux substrate.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Clinical Center

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/msphere.00673-22

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