Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 + Hematopoietic Progenitor Cells from Apoptosis-Reference-Cited by-同舟云学术

Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34 + Hematopoietic Progenitor Cells from Apoptosis

Published:2021-02-24 Issue:1 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Hancock Meaghan H.¹^ORCID,Crawford Lindsey B.¹^ORCID,Perez Wilma¹,Struthers Hillary M.¹,Mitchell Jennifer¹,Caposio Patrizia¹^ORCID

Affiliation:

1. Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon, USA

Abstract

Human cytomegalovirus (HCMV) causes serious disease in immunocompromised individuals and is a significant problem during transplantation. The virus can establish a latent infection in CD34 + hematopoietic progenitor cells (HPCs) and periodically reactivate to cause disease in the absence of an intact immune system.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00986-20

Reference56 articles.

1. Definitions of Cytomegalovirus Infection and Disease in Transplant Recipients

2. Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients

3. The pathogenesis of human cytomegalovirus