Affiliation:
1. Department of Medicine, Albert Einstein College of Medicine, New York, New York, USA
2. Department of Pathology, Albert Einstein College of Medicine, New York, New York, USA
Abstract
ABSTRACT
Laura Cheney works at the crossroads of HIV and autophagy, a critical biological process for cellular homeostasis, to understand more completely the pathogenesis of HIV-associated neurocognitive impairment. In this mSphere of Influence article, she reflects on how “A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag” by Willa Wen-You Yim, Hayashi Yamamoto, and Noboru Mizushima (eLife 11:e78923, 2022,
https://doi.org/10.7554/eLife.78923
) expands the tools for studying autophagy and inspired her to use this technology to develop a reporter to study autophagy of mitochondria, termed mitophagy, to further her own research goals.
Funder
HHS | NIH | National Institute of Mental Health
YU | AECOM | Einstein-Rockefeller-CUNY Center for AIDS Research, Albert Einstein College of Medicine
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology