Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population-Reference-Cited by-同舟云学术

Association of Major Histocompatibility Complex Class 1 Chain-Related Gene A Dimorphism with Type 1 Diabetes and Latent Autoimmune Diabetes in Adults in the Algerian Population

Published:2012-04 Issue:4 Volume:19 Page:557-561
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Raache Rachida¹²,Belanteur Khadidja²,Amroun Habiba²,Benyahia Amel³,Heniche Amel²,Azzouz Malha⁴,Mimouni Safia⁴,Gervais Thibaud⁵,Latinne Dominique⁵,Boudiba Aissa⁴,Attal Nabila²,Abbadi Mohamed Cherif²

Affiliation:

1. Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene, Algiers, Algeria

2. Service d'Immunologie, Institut Pasteur d'Algérie, Algiers, Algeria

3. Laboratoire Central de biologie, CHU N′Fissa Hamoud, Hussein Dey, Algiers, Algeria

4. Service de Diabétologie CHU Mustapha, Algiers, Algeria

5. Laboratoire d'Immunohématologie, Cliniques Universitaires Saint Luc, Brussels, Belgium

Abstract

ABSTRACT Major histocompatibility complex class I chain-related gene A (MICA-129) dimorphism was investigated in 73 autoimmune diabetes patients (type 1 diabetes and latent autoimmune diabetes in adults) and 75 controls from Algeria. Only MICA-129 Val allele and MICA-129 Val/Val genotype frequencies were higher among patients than in the control group. Statistical analysis of the estimated extended HLA-DR-DQ-MICA haplotypes shown that individual effects of MICA alleles on HLA-DQ2-DR3-MICA-129 Val/Val and HLA-DQ8-DR4-MICA-129 Val/Val haplotypes were significantly higher in patients than in the control groups. These preliminary data might suggest a relevant role of MICA-129 Val/Val single nucleotide polymorphism (weak/weak binders of NKG2D receptor) in the pathogenesis of T1D and LADA.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.05473-11

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