Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells-Reference-Cited by-同舟云学术

Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells

Published:2008-08-15 Issue:16 Volume:82 Page:8215-8223
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chang Jinhong¹,Guo Ju-Tao¹,Jiang Dong¹,Guo Haitao¹,Taylor John M.²,Block Timothy M.¹³

Affiliation:

1. Drexel Institute for Biotechnology and Virology Research, Department of Microbiology and Immunology, Drexel University College of Medicine

2. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111

3. Institute for Hepatitis and Virus Research, Hepatitis B Foundation, 3805 Old Easton Road, Doylestown, Pennsylvania 18902

Abstract

ABSTRACT The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02575-07

Reference49 articles.

1. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol.4:499-511.

2. Hepatitis C Virus Subgenomic Replicons in the Human Embryonic Kidney 293 Cell Line

3. Ambros, V. 2004. The functions of animal microRNAs. Nature431:350-355.

4. MicroRNAs

5. Berkhout, B., and K. T. Jeang. 2007. RISCy business: microRNAs, pathogenesis, and viruses. J. Biol. Chem.282:26641-26645.

Cited by 191 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Binding of microRNA-122 to the hepatitis C virus 5′ untranslated region modifies interactions with poly(C) binding protein 2 and the NS5B viral polymerase;Nucleic Acids Research;2023-11-06

2. Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study;Signal Transduction and Targeted Therapy;2023-03-02

3. Normalization of circulating plasma levels of miRNAs in HIV-1/HCV co-infected patients following direct-acting antiviral–induced sustained virologic response;Heliyon;2023-01

4. Appling Drug Discovery in HCV-therapeutics: A snapshot from the past and glimpse into the future;Hepatitis C Virus-Host Interactions and Therapeutics: Current Insights and Future Perspectives;2023-01

5. Hepatitis C;Encyclopedia of Cell Biology;2023