Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation-Reference-Cited by-同舟云学术

Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation

Published:2022-11-09 Issue:21 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhong Youquan¹²,Wu Chuanjian¹,Xu Zaichao¹,Teng Yan¹,Zhao Li¹,Zhao Kaitao¹^ORCID,Wang Jingjing¹,Wang Wen³,Zhan Qiong¹,Zhu Chengliang⁴,Chen Xinwen⁵^ORCID,Liang Kaiwei³,Cheng Xiaoming¹⁶⁷,Xia Yuchen¹^ORCID

Affiliation:

1. State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China

2. Department of Laboratory Medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

3. Department of Pathophysiology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan University, Wuhan, China

4. Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China

5. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

6. Wuhan University Center for Pathology and Molecular Diagnostics, Zhongnan Hospital of Wuhan University, Wuhan, China

7. Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China

Abstract

Hepatitis B virus (HBV) core protein (HBc) has emerged as a promising antiviral target. However, whether HBc can regulate HBV covalently closed circular DNA (cccDNA) transcription remains elusive. This study illustrated that HBc has no effect on epigenetic regulation of cccDNA, and it does not participate in cccDNA transcription. Given that HBc is dispensable for cccDNA transcription, novel cccDNA-targeting therapeutics are needed for an HBV cure.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01362-22

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