Elucidation of the Late Steps during Hexacosalactone A Biosynthesis in Streptomyces samsunensis OUCT16-12

Author:

Duan He1,Wang Fang1,Zhang Chuchu1,Dong Yujing1,Li Huayue12,Xiao Fei1,Li Wenli12ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China

2. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China

Abstract

In this study, we elucidate the post-PKS tailoring steps during the biosynthesis of compound 1 and demonstrate that both C 5 N and 15- O Me groups are critical for the antibacterial activities of compound 1, paving the way for generation of hexacosalactone derivatives via synthetic biology strategy. In addition, mining of HexABC homologs from the GenBank database revealed their wide distribution across the bacterial world, facilitating the discovery of other bioactive natural products with C 5 N moiety.

Funder

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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