Age-Related Susceptibility to Haemophilus influenzae Type b Disease in Rabbits-Reference-Cited by-同舟云学术

Age-Related Susceptibility to Haemophilus influenzae Type b Disease in Rabbits

Published:1971-10 Issue:4 Volume:4 Page:397-401
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Schneerson Rachel¹,Robbins John B.²

Affiliation:

1. Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York

2. National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Anti-type b antibodies were detected in newborns and in most 6- to 8-week-old rabbits, similar to those observed in humans. Culture of the pharynx and rectum of rabbits at varied ages failed to yield Haemophilus influenzae type b. Bacteria with cross-reacting antigens were observed in both the pharyngeal and rectal cultures from rabbits of varied ages. Rabbits without preexisting serum anti-type b antibodies were highly susceptible to septicemia and death after injection of small numbers of H. influenzae type b. Passively acquired antibody, whether observed in newborns or injected into animals without preexisting antibodies, conferred a high degree of protection against H. influenzae type b.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.4.4.397-401.1971

Reference37 articles.

1. The piathogenicity of bacillus influenzae for laborattory ainirmials;Albert H.;J. Inifec. Dis.,1919

2. Treatmient of Haemiiophilus influent:ae infections anid of meningococcic and pneumiiococcic meningitis;Alexander H. E.;Amer. J. Dis. Child.,1943

3. Type b anti-influenzall r.abbit serum for therapeutic purposes;Alexander H. E.;Proc. Soc. Exp. Biol. Med.,1939

4. Alexander H. E. 1965. The Hemophilus group p. 734. Mli R. J Dubos and J. G. Hirsch (ed.) Bacterial aind mycotic infections in man 4th ed. J. B. Lippincott Co. Philadelphia.

5. The protective or curative element in type b H. i,,fluenZae;Alexander H. E.;Yale J. Biol. Med.,1944

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