Affiliation:
1. Department of Veterinary Science, The Pennsylvania State University, University Park, Pennsylvania 16802
Abstract
Mice were injected intraperitoneally with 50 μg of
Escherichia coli
lipopolysaccharide (LPS). The spleen tissue exhibited increased histamine-forming capacity (HFC) 4 hr later. When this increased HFC was produced within 12 hr after intraperitoneal injection of sheep red blood cells (SRBC), there was an enhanced anti-SRBC antibody response in the spleen. In mice experiencing an increased spleen HFC at 36 hr after injection of SRBC, there was a significant decrease in the number of antibody-producing cells. The injection of histidine decarboxylase inhibitors simultaneously with the LPS greatly reduced the stimulation of HFC and also the adjuvant activity of the LPS.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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