Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting-Reference-Cited by-同舟云学术

Xpert MTB/RIF Ultra Is Highly Sensitive for the Diagnosis of Tuberculosis Lymphadenitis in a High-HIV Setting

Published:2021-11-18 Issue:12 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Minnies Stephanie¹,Reeve Byron W. P.¹,Rockman Loren¹,Nyawo Georgina¹,Naidoo Charissa C.¹,Kitchin Natasha²,Rautenbach Cornelia³⁴,Wright Colleen A.⁵,Whitelaw Andrew³⁴,Schubert Pawel⁴⁵,Warren Robin M.¹,Theron Grant¹

Affiliation:

1. DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Republic of South Africa

2. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Republic of South Africa

3. Division of Medical Microbiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Republic of South Africa

4. National Health Laboratory Services, Cape Town, Republic of South Africa

5. Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Republic of South Africa

Abstract

Tuberculosis lymphadenitis (TBL) is the most common extrapulmonary tuberculosis (EPTB) manifestation. Xpert MTB/RIF Ultra (Ultra) is a World Health Organization-endorsed diagnostic test, but performance data for TBL, including on noninvasive specimens, are limited. Fine-needle aspiration biopsy specimens (FNABs) from outpatients (≥18 years) with presumptive TBL ( n = 135) underwent (i) routine Xpert MTB/RIF testing (later with Ultra once programmatically available), (ii) an MGIT 960 culture (if Xpert or Ultra negative or rifampin resistant), and (iii) study Ultra testing. Concentrated paired urine specimens underwent Ultra testing.

Funder

South African Medical Research Council

European and Developing Countries Clinical Trials Partnership

HHS | National Institutes of Health

National Research Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01316-21

Reference32 articles.