LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes-Reference-Cited by-同舟云学术

LipA, a Tyrosine and Lipid Phosphatase Involved in the Virulence of Listeria monocytogenes

Published:2011-06 Issue:6 Volume:79 Page:2489-2498
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kastner Renate¹,Dussurget Olivier²³⁴⁵,Archambaud Cristel²³⁴,Kernbauer Elisabeth¹,Soulat Didier¹,Cossart Pascale²³⁴,Decker Thomas¹

Affiliation:

1. Max F. Perutz Laboratories, Department of Microbiology, Immunobiology and Genetics, University of Vienna, Dr. Bohr-Gasse 9/4, 1030 Vienna, Austria

2. Unité des Interactions Bactéries-Cellules, Institut Pasteur, F-75015 Paris, France

3. Inserm U604, F-75015 Paris, France

4. INRA USC2020, F-75015 Paris, France

5. University Paris 7, F-75013 Paris, France

Abstract

ABSTRACTIntracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. TheListeria monocytogenesgenome contains a gene,lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that thelmo1800-encoded protein LipA is secreted byListeriaand displays tyrosine as well as lipid phosphatase activityin vitro. Bacteria lacking LipA are severely attenuated in virulencein vivo, thus revealing a so-far-undescribed enzymatic activity involved inListeriainfection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.05073-11

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