Proteome, Bioinformatic, and Functional Analyses Reveal a Distinct and Conserved Metabolic Pathway for Bile Salt Degradation in the Sphingomonadaceae-Reference-Cited by-同舟云学术

Proteome, Bioinformatic, and Functional Analyses Reveal a Distinct and Conserved Metabolic Pathway for Bile Salt Degradation in the Sphingomonadaceae

Published:2021-09-10 Issue:19 Volume:87 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Feller Franziska M.¹,Wöhlbrand Lars²,Holert Johannes¹,Schnaars Vanessa²,Elsner Lea¹,Mohn William W.³^ORCID,Rabus Ralf²^ORCID,Philipp Bodo¹⁴^ORCID

Affiliation:

1. Microbial Biotechnology and Ecology, Institute for Molecular Microbiology and Biotechnology, Westfälische Wilhelms-Universität Münster, Münster, Germany

2. General and Molecular Microbiology, Institute for Chemistry and Biology of the Marine Environment (ICBM), Carl von Ossietzky University of Oldenburg, Oldenburg, Germany

3. Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, Canada

4. Applied Ecology and Bioresources, Fraunhofer-Institute for Molecular and Applied Ecology IME, Schmallenberg, Germany

Abstract

This study highlights the biochemical diversity of bacterial degradation of steroid compounds in particular bile salts. Furthermore, it substantiates and advances knowledge of a variant pathway for degradation of steroids by sphingomonads, a group of environmental bacteria that are well known for their broad metabolic capabilities.

Funder

Deutsche Forschungsgemeinschaft

Deutscher Akademischer Austauschdienst

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00987-21

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