Molecular Cloning and Physical Mapping of the Daptomycin Gene Cluster from Streptomyces roseosporus-Reference-Cited by-同舟云学术

Molecular Cloning and Physical Mapping of the Daptomycin Gene Cluster from Streptomyces roseosporus

Published:1998-01 Issue:1 Volume:180 Page:143-151
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Mchenney Margaret A.¹,Hosted Thomas J.¹,Dehoff Bradley S.¹,Rosteck Paul R.¹,Baltz Richard H.¹

Affiliation:

1. Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285

Abstract

ABSTRACT The daptomycin biosynthetic gene cluster of Streptomyces roseosporus was analyzed by Tn 5099 mutagenesis, molecular cloning, partial DNA sequencing, and insertional mutagenesis with cloned segments of DNA. The daptomycin biosynthetic gene cluster spans at least 50 kb and is located about 400 to 500 kb from one end of the ∼7,100-kb linear chromosome. We identified two peptide synthetase coding regions interrupted by a 10- to 20-kb region that may encode other functions in lipopeptide biosynthesis.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.180.1.143-151.1998

Reference38 articles.

1. δ-(l-α-Aminoadipyl)-l-cysteinyl-d-valine synthetase, the multienzyme integrating the four primary reactions in β-lactam biosynthesis, as a model peptide synthetase;Aharonowitz Y.;Bio/Technology,1992

2. Basic local alignment research tool;Altschul S. F.;J. Mol. Biol.,1990

3. Genetic recombination in Streptomyces fradiae by protoplast fusion and cell regeneration;Baltz R. H.;J. Gen. Microbiol.,1978

4. Baltz R. H. Lipopeptide antibiotics produced by Streptomyces roseosporus and Streptomyces fradiae Biotechnology of industrial antibiotics 2nd ed. Strohl W. R. 1997 415 Marcel Dekker Inc. New York N.Y

5. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp;Bierman M.;Gene,1992

Cited by 49 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces;Natural Product Reports;2023

2. A new bacterial tRNA enhances antibiotic production in Streptomyces by circumventing inefficient wobble base-pairing;Nucleic Acids Research;2022-06-14

3. Streptomyces-based cell factories for production of biomolecules and bioactive metabolites;Microbial Cell Factories Engineering for Production of Biomolecules;2021

4. Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review;Pathogens;2020-06-29

5. The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry;MedChemComm;2019