Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance-Reference-Cited by-同舟云学术

Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance

Published:1996-01 Issue:1 Volume:40 Page:221-224
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bauernfeind A¹,Stemplinger I¹,Jungwirth R¹,Giamarellou H¹

Affiliation:

1. Max von Pettenkofer-Institut, Munich, Germany.

Abstract

The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.1.221

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