In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH 2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci-Reference-Cited by-同舟云学术

In Vitro Activities of the Lipopeptides Palmitoyl (Pal)-Lys-Lys-NH 2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-Positive Cocci

Published:2007-01 Issue:1 Volume:51 Page:354-358
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kamysz Wojciech¹,Silvestri Carmela²,Cirioni Oscar²,Giacometti Andrea²,Licci Alberto²,Della Vittoria Agnese²,Okroj Marcin³,Scalise Giorgio²

Affiliation:

1. Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland

2. Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy

3. Lund University, Department of Laboratory Medicine, Malmö University Hospital, Malmö, Sweden

Abstract

ABSTRACT The in vitro activities of the lipopeptides palmitoyl (Pal)-Lys-Lys-NH 2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi . A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00344-06

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