Impact of N -Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp-Reference-Cited by-同舟云学术

Impact of N -Chlorotaurine on Viability and Production of Secreted Aspartyl Proteinases of Candida spp

Published:2002-06 Issue:6 Volume:46 Page:1996-1999
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nagl Markus¹,Gruber Andreas¹,Fuchs Anita¹,Lell Claudia P.¹,Lemberger Eva-Maria¹,Borg-von Zepelin Margarete²,Würzner Reinhard¹

Affiliation:

1. Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Innsbruck, Austria

2. Institute of Bacteriology, University Clinics of Göttingen, Göttingen, Germany

Abstract

ABSTRACT N -Chlorotaurine, an endogenous long-lived oxidant, demonstrated fungicidal activity against Candida spp. and a postantifungal effect. Secreted aspartyl proteinases, important fungal virulence factors, proved to be a first target of impact. These results provide support for the topical application of N -chlorotaurine as an antimicrobial agent in yeast infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.6.1996-1999.2002

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