Severe Thrombocytopenia Associated with Acute Hepatitis E Virus Infection

Author:

Colson P.12,Payraudeau E.1,Leonnet C.3,De Montigny S.4,Villeneuve L.3,Motte A.1,Tamalet C.12

Affiliation:

1. Laboratoire de Virologie, Fédération Hospitalière de Bactériologie-Virologie Clinique, Centre Hospitalo-Universitaire Timone, 264 Rue Saint-Pierre 13385, Marseille Cedex 05, France

2. URMITE CNRS-IRD UMR 6236, Faculté de Médecine et de Pharmacie, Université de la Méditerranée (Aix-Marseille-II), 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France

3. Laboratoire de Biologie Médicale, Centre Hospitalier d'Aubagne, 179 Avenue des Soeurs Gastine, 13677 Aubagne Cedex, France

4. Service d'Hépato-Gastro-Entérologie, Centre Hospitalier d'Aubagne, 179 Avenue des Soeurs Gastine, 13677 Aubagne Cedex, France

Abstract

ABSTRACT We describe here what is, to the best of our knowledge, the third reported case of severe thrombocytopenia associated with acute hepatitis E virus infection. The patient was a 72-year-old French woman. It seems likely that the cause of the thrombocytopenia was acute hepatitis E virus infection, possibly occurring via an immune mechanism. No complications were noted, in contrast to the two previous reports.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference14 articles.

1. Ali, G., M. Kumar, S. K. Bali, and W. B. Wadhwa. 2001. Hepatitis E associated thrombocytopaenia and membranous glomerulonephritis. Indian J. Nephrol.11:70-72.

2. Bulang, T., and H. Porst. 2000. Hepatitis E after travel to India: two case reports. Z Gastroenterol.38:249-253.

3. Colson, P., C. Coze, P. Gallian, M. Henry, P. De Micco, and C. Tamalet. 2007. Transfusion-transmitted hepatitis E in a child in France. Emerg. Infect. Dis.13:648-649.

4. Reference deleted.

5. Dalton, H. R., S. Hazeldine, M. Banks, S. Ijaz, and R. Bendall. 2007. Locally acquired hepatitis E in chronic liver disease. Lancet369:1260.

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