Aspergillus nidulans Natural Product Biosynthesis Is Regulated by MpkB, a Putative Pheromone Response Mitogen-Activated Protein Kinase-Reference-Cited by-同舟云学术

Aspergillus nidulans Natural Product Biosynthesis Is Regulated by MpkB, a Putative Pheromone Response Mitogen-Activated Protein Kinase

Published:2008-06 Issue:11 Volume:74 Page:3596-3600
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Atoui Ali¹,Bao Dapeng¹,Kaur Navgeet¹,Grayburn W. Scott¹,Calvo Ana M.¹

Affiliation:

1. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115

Abstract

ABSTRACT The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA , which has been found to regulate secondary metabolism gene clusters.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02842-07

Reference48 articles.

1. Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi

2. Bardwell, L. 2006. Mechanisms of MAPK signaling specificity. Biochem. Soc. Trans.34:837-841.

3. Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans

4. LaeA, a Regulator of Secondary Metabolism in Aspergillus spp

5. Bouhired, S., M. Weber, A. Kempf-Sontag, N. P. Keller, and D. Hoffmeister. 2007. Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet. Biol.44:1134-1145.

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis;Applied and Environmental Microbiology;2024-09-04

2. Fus3 regulates asexual development and trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora;iScience;2023-08

3. Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans;Microbiology Spectrum;2023-04-13

4. Transcriptomic analysis of genes: expression and regulation;Transcriptome Profiling;2023

5. The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis;Nucleic Acids Research;2022-09-12