Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa-Reference-Cited by-同舟云学术

Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa

Published:1999-02 Issue:2 Volume:73 Page:1708-1714
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Dorrell Lucy¹,Dong Tao¹,Ogg Graham S.¹,Lister Simon²,McAdam Steve¹,Rostron Tim¹,Conlon Chris³,McMichael Andrew J.¹,Rowland-Jones Sarah L.¹

Affiliation:

1. Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS,1

2. Department of Genito-Urinary Medicine, Imperial College School of Medicine, London W2 1PG,2 and

3. Nuffield Department of Medicine, John Radcliffe Hospital, Oxford OX3 9DU,3 United Kingdom

Abstract

ABSTRACT We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.2.1708-1714.1999

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