Affiliation:
1. Departments of Medical Microbiology and Immunology1 and of
2. Surgery,2 Göteborg University, Göteborg, Sweden
Abstract
ABSTRACT
Using immunohistochemical staining, we examined the presence of secretory component (SC) on epithelial cells in gastric and duodenal biopsy specimens collected from
Helicobacter pylori
-infected individuals and healthy controls. Gastric epithelial cells from healthy volunteers expressed low, but detectable, levels of SC. In contrast, significantly higher level of expression of SC (
P
< 0.001) was observed on epithelial cells in the antra of
H. pylori
-infected individuals. The antral SC expression correlated with staining for gamma interferon of intraepithelial and lamina propria lymphocytes (
r
s
= 0.76 and 0.69, respectively,
P
< 0.001) and correlated weakly with production of tumor necrosis factor alpha (
r
s
= 0.43,
P
< 0.05), but it did not correlate at all with interleukin-4 production.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
23 articles.
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