Interplay of Amino Acid Residues at Positions 28 and 31 in NS5A Defines Resistance Pathways in Hepatitis C Virus Genotype 2-Reference-Cited by-同舟云学术

Interplay of Amino Acid Residues at Positions 28 and 31 in NS5A Defines Resistance Pathways in Hepatitis C Virus Genotype 2

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Asante-Appiah Ernest¹^ORCID,Ingravallo Paul¹,McMonagle Patricia¹,Bystol Karin¹,Xia Ellen²,Curry Stephanie¹,Qiu Ping³,Black Stuart¹,Chase Robert¹,Liu Rong¹,Lahser Fred¹^ORCID

Affiliation:

1. Department of Infectious Diseases, Merck & Co., Inc., Kenilworth, New Jersey, USA

2. Department of In Vitro Pharmacology, Merck & Co., Inc., Kenilworth, New Jersey, USA

3. Department of Translational Molecular Biomarkers, Merck & Co., Inc., Kenilworth, New Jersey, USA

Abstract

Hepatitis C virus (HCV) genotype 2 (GT2) represents approximately 9% of all viral infections globally. While treatment outcomes for GT2-infected patients have improved substantially with direct-acting antiviral agents (DAAs) compared to alpha interferon, the presence of polymorphisms in NS5A can impact the efficacy of NS5A inhibitor-containing regimens. Thus, pathways of NS5A resistance were explored in GT2 subtypes using elbasvir, an NS5A inhibitor with broad genotype activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01269-19

Reference40 articles.

1. Global epidemiology and genotype distribution of the hepatitis C virus infection

2. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence

3. WHO. 2017. Global hepatitis report 2017. World Health Organization. http://www.who.int/hepatitis/publications/global-hepatitis-report2017/en/. Accessed 15 March 2018.

4. Hepatitis C virus: Promising discoveries and new treatments

5. Virology and cell biology of the hepatitis C virus life cycle – An update

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of Indole-Fused Six-, Seven-, or Eight-Membered N,O-Heterocycles via Rhodium-Catalyzed NH-Indole-Directed C–H Acetoxylation/Hydrolysis/Annulation;The Journal of Organic Chemistry;2021-11-10

2. Cell Culture Studies of the Efficacy and Barrier to Resistance of Sofosbuvir-Velpatasvir and Glecaprevir-Pibrentasvir against Hepatitis C Virus Genotypes 2a, 2b, and 2c;Antimicrobial Agents and Chemotherapy;2020-02-21