Low-Level Parasite Persistence Drives Vasculitis and Myositis in Skeletal Muscle of Mice Chronically Infected with Trypanosoma cruzi-Reference-Cited by-同舟云学术

Low-Level Parasite Persistence Drives Vasculitis and Myositis in Skeletal Muscle of Mice Chronically Infected with Trypanosoma cruzi

Published:2019-06 Issue:6 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Weaver Joseph D.¹,Hoffman Victoria J.²,Roffe Ester¹,Murphy Philip M.¹

Affiliation:

1. Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. Division of Veterinary Resources, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, Maryland, USA

Abstract

In chronic Trypanosoma cruzi infection, the cause of Chagas disease, life-threatening inflammatory diseases develop over time in the heart, esophagus, and colon of some patients. C57BL/6 mice infected with the myotropic Colombiana strain of T. cruzi model many of the immunological and parasitological features of human infection but succumb to chronic paralyzing myositis and skeletal muscle vasculitis, not cardiomyopathy or gastrointestinal disease.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00081-19

Reference54 articles.

1. Chagas disease

2. Host cell invasion byTrypanosoma cruzi: a unique strategy that promotes persistence

3. Pathophysiology of the heart in Chagas' disease: current status and new developments