The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts-Reference-Cited by-同舟云学术

The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts

Published:2019-12-11 Issue:1 Volume:40 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Hosoyamada Shun¹²,Sasaki Mariko¹,Kobayashi Takehiko¹²³^ORCID

Affiliation:

1. Institute for Quantitative Biosciences (IQB), Tokyo, Japan

2. Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan

3. Collaborative Research Institute for Innovative Microbiology, University of Tokyo, Tokyo, Japan

Abstract

The rRNA genes (rDNA) in eukaryotes are organized into highly repetitive gene clusters. Each organism maintains a particular number of copies, suggesting that the rDNA is actively stabilized. We previously identified about 700 Saccharomyces cerevisiae genes that could contribute to rDNA maintenance. Here, we further analyzed these deletion mutants with unstable rDNA by measuring the amounts of extrachromosomal rDNA circles (ERCs) that are released as by-products of intrachromosomal recombination.

Funder

Japan Society for the Promotion of Science

Takeda Science Foundation

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00320-19

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1. The economics of ribosome biosynthesis in yeast