Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway-Reference-Cited by-同舟云学术

Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway

Published:2022-01-20 Issue:1 Volume:42 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Jiang Aiwen¹,Guo Hongyun¹,Zhang Liangliang¹,Jiang Xiaoyu¹,Zhang Xiying¹,Wu Wangjun¹^ORCID,Liu Honglin¹

Affiliation:

1. Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China

Abstract

The activity of AMP-activated protein kinase α (AMPKα) is reduced in type 2 diabetes, and type 2 diabetes is associated with muscular atrophy. To date, there is little known about the mechanism by which free fatty acid (FFA) participates in muscular impairment.

Funder

The major Agricultural Plan of New Variety Innovation of Jiangsu Province

The National Major Project of breeding for Transgenic pigs

Natural Science Foundation of Jiangsu Province

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00327-21

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1. Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr