Specificity of a protective memory immune response against Mycobacterium tuberculosis

Author:

Andersen P1,Heron I1

Affiliation:

1. Bacterial Vaccine Department, Statens Seruminstitut, Copenhagen S, Denmark.

Abstract

We have investigated the memory T-cell immune response to Mycobacterium tuberculosis infection. C57BL/6J mice infected with M. tuberculosis were found to generate long-lived memory immunity which provided a heightened state of acquired resistance to a secondary infection. The T-cell response of memory immune mice was directed to all parts of the bacilli, i.e., both secreted and somatic proteins. Major parts of the memory T-cell repertoire were maintained in a highly responsive state by cross-reactive restimulation with antigens present in the normal microbiological environment of the animals. A resting non-cross-reactive part of the memory repertoire was restimulated early during a secondary infection to expand and produce large amounts of gamma interferon. The molecular target of these T cells was identified as a secreted mycobacterial protein with a molecular mass of 3 to 9 kDa.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference43 articles.

1. The secreted antigens of Mycobacterium tuberculosis and their relationship to those recognized by the available antibodies;Abou-Zeid C.;J. Gen. Microbiol.,1988

2. Andersen P. Unpublished data.

3. Identification of immunodominant antigens during infection with Mycobacterium tuberculosis;Andersen P.;Scand. J. Immunol.,1992

4. Proteins released from Mycobacterium tuberculosis during growth;Andersen P.;Infect. Immun.,1991

5. T-cell proliferative response to antigens secreted from Mycobactenum tuberculosis;Andersen P.;Infect. Immun.,1991

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