Isolation and Characterization of a Novel Francisella sp. from Human Cerebrospinal Fluid and Blood

Author:

Kugeler Kiersten J.1,Mead Paul S.1,McGowan Karin L.2,Burnham Jon M.2,Hogarty Michael D.2,Ruchelli Eduardo2,Pollard Kerry3,Husband Brigitte3,Conley Caryn4,Rivera Tanya4,Kelesidis Theodoros5,Lee Walter M.5,Mabey Walburga5,Winchell Jonas M.6,Stang Heather L.6,Staples J. Erin1,Chalcraft Linda J.1,Petersen Jeannine M.1

Affiliation:

1. Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado

2. Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

3. Bureau of Laboratories, Pennsylvania Department of Health, Lionville, Pennsylvania

4. Massachusetts Department of Public Health State Laboratory Institute, Jamaica Plain, Massachusetts

5. Caritas St. Elizabeth's Medical Center, Boston, Massachusetts

6. Division of Bioterrorism Preparedness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

ABSTRACT We describe the isolation of a Francisella sp. from normally sterile sites in acutely ill patients in two different states within 2 years. Microbiologic and molecular analyses indicate that this organism represents a novel Francisella sp. Clinicians and microbiologists should be aware of this new potential pathogen, as infection may be more common than recognized.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference19 articles.

1. Detection of Diverse New Francisella -Like Bacteria in Environmental Samples

2. Chu, M. C., and R. Weyant. 2003. Francisella and Brucella, p. 789-797. In P. R. Murray, E. J. Baron, J. H. Jorgensen, M. A. Pfaller, and R. H. Yolken (ed.), Manual of clinical microbiology, 8th ed. American Society for Microbiology, Washington, DC.

3. Characterization of two unusual clinically significant Francisella strains

4. Cross, J. T., and R. F. Jacobs. 1993. Tularemia: treatment failures with outpatient use of ceftriaxone. Clin. Infect. Dis.17:976-980.

5. Tularemia

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