Neutrophil-Activating Protein Mediates Adhesion of Helicobacter pylori to Sulfated Carbohydrates on High-Molecular-Weight Salivary Mucin-Reference-Cited by-同舟云学术

Neutrophil-Activating Protein Mediates Adhesion of Helicobacter pylori to Sulfated Carbohydrates on High-Molecular-Weight Salivary Mucin

Published:1998-02 Issue:2 Volume:66 Page:444-447
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Namavar Ferry¹,Sparrius Marion¹,Veerman Enno C. I.²,Appelmelk Ben J.¹,Vandenbroucke-Grauls Christina M. J. E.¹

Affiliation:

1. Departments of Medical Microbiology1 and

2. Oral Biochemistry,2 Medical School, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands

Abstract

ABSTRACT The in vitro binding of surface-exposed material and outer membrane proteins of Helicobacter pylori to high-molecular-weight salivary mucin was studied. We identified a 16-kDa surface protein which adhered to high-molecular-weight salivary mucin. This protein binds specifically to sulfated oligosaccharide structures such as sulfo-Lewis a, sulfogalactose and sulfo- N -acetyl-glucosamine on mucin. Sequence analysis of the protein proved that it was identical to the N-terminal amino acid sequence of neutrophil-activating protein. Moreover, this adhesin was able to bind to Lewis x blood group antigen.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.2.444-447.1998

Reference41 articles.

1. Isolation of a cell surface component of Helicobacter pylori that binds H type 2, Lewisa, and Lewisb antigens.;Alkout A. M.;Gastroentrology,1997

2. Affinity of the gastric pathogen Helicobacter pylori for the N-sulphated glycosaminoglycan heparan sulphate.;Ascencio F.;J. Med. Microbiol.,1993

3. Helicobacter pylori interaction with heparin and heparin-dependent growth factor.;Ascencio F.;FEMS Immunol. Med. Microbiol.,1995

4. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation.;Blaser M. J.;J. Infect. Dis.,1990

5. Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.;Borén T.;Science,1993

Cited by 122 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cathartocytosis: How Cells Jettison Unwanted Material as They Reprogram;2024-06-13

2. How Long Will It Take to Launch an Effective Helicobacter pylori Vaccine for Humans?;Infection and Drug Resistance;2023-06

3. 3′-sulfated LewisA/C: An oncofetal epitope associated with metaplastic and oncogenic plasticity of the gastrointestinal foregut;Frontiers in Cell and Developmental Biology;2023-02-14

4. The Role of Helicobacter pylori Neutrophil-Activating Protein in the Pathogenesis of H. pylori and Beyond: From a Virulence Factor to Therapeutic Targets and Therapeutic Agents;International Journal of Molecular Sciences;2022-12-21

5. mAb Das-1 recognizes 3’-Sulfated Lewis A/C, which is aberrantly expressed during metaplastic and oncogenic transformation of several gastrointestinal Epithelia;PLOS ONE;2021-12-15