Author:
Lerner S A,Friedman E L,Dudek E J,Kominski G,Bohnhoff M,Morello J A
Abstract
A clinical isolate of Neisseria gonorrhoeae with an unusual growth requirement for isoleucine and valine lacked the activity of acetohydroxy acid synthetase, one of the enzymes required for the biosynthesis of these amino acids. A spontaneous mutant which no longer required isoleucine and valine had acquired this enzymatic activity.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference28 articles.
1. The metabolism of valine and isoleucine in E. coli. XVII. The role of induction in the derepression of acetohydroxyacid isomerase;Arfin S. M.;Biochem. Biophys. Res. Commun.,1969
2. Isoleucinevaline requiring mutants of Salmonella typhimurium;Armstrong F. B.;Genetics,1964
3. Control of isoleucine, valine and leucine biosynthesis. II. Endproduct inhibition by valine of acetohydroxy acid synthetase in Salmonella typhimurium;Bauerle R. H.;Biochim. Biophys. Acta,1964
4. The biosynthesis of leucine. III. The conversion of ahydroxy-,8-carboxyisocaproate to a-ketoisocaproate;Burns R. O.;Biochemistry,1963
5. Crawford G. J. S. Knapp J. Hale and K. K. Holmes.
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