Novel R-Plasmid-Mediated Beta-Lactamase from Klebsiella aerogenes

Author:

Petrocheilou V.1,Sykes R. B.1,Richmond M. H.2

Affiliation:

1. Glaxo Research Limited, Greenford, Middlesex, England

2. Department of Bacteriology, University of Bristol, University Walk, Bristol, BS8 1TD, England,

Abstract

A novel β-lactamase with a broad spectrum of activity against penicillins and cephalosporins has been detected in a strain of Klebsiella aerogenes . Its synthesis is mediated by an R-plasmid of molecular weight 64 × 10 6 .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Resistance of Escherichia coli to penicillins: identification of the structural gene for chromosomal penicillinase;Burman L. G.;J. Bacteriol.,1973

2. The purification and properties of a penicillinase whose synthesis is mediated by an R-factor in Enterobacteriaceae;Datta N.;Biochem. J.,1966

3. Distribution of R-plasmids among the 0-antigen types ofEscherichia coli isolated from human and animal sources;Hartley C. L.;Antimicrob. Agents Chemother.,1975

4. A comparative study of eight distinct (3-lactamases synthesised by Gram-negative bacteria;Jack G. W.;J. Gen. Microbiol.,1970

5. The use of analytical iso-electric focusing for detection and identification of ,3-lactamases;Matthew M.;J. Gen. Microbiol.,1975

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