Affiliation:
1. ICN Nucleic Acid Research Institute, ICN Pharmaceuticals, Inc., Irvine, California 92715
Abstract
3-Deazaguanine (ICN 4221), 3-deazaguanosine (ICN 4793), and 3-deazaguanylic acid (ICN 5412) represent a new class of synthetic guanine analogs having antiviral activity. In vitro, nine ribonucleic acid and seven deoxyribonucleic acid viruses were inhibited, including influenza, parainfluenza, rhino-, vesicular stomatitis, adeno-, herpes-, cytomegalo-, vaccinia, pseudorabies, and myxoma viruses. They were effective orally against influenza types A and B and parainfluenza type 1 (Sendai) virus infections in mice, with a therapeutic index of 16 against the latter two viruses. The course of herpes encephalitis was altered only when the drugs were applied directly into the brain. In addition, these drugs were effective inhibitors of Friend leukemia virus-induced splenomegaly in mice; treatment also produced extensions of life in these animals.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference11 articles.
1. Target-organ treatment of neurotropic virus diseases: efficacy as a chemotherapy tool and comparison of activity of adenine arabinoside, cytosine arabinoside, idoxuridine, and trifluorothymidine;Allen L. B.;Antimicrob. Agents Chemother.,1972
2. Antiviral effect of purine antagonists against Rauikhet disease virus in stationary culture of chorioallantoic membrane of chick embryos;Babbar 0.;J. Sci. Ind. Res.,1961
3. Synthesis of 3- deazaguanine, 3-deazaguanosine, and 3-deazaguanylic acid by a novel ring closure of imidazole precursors;Cook P. D.;J. Am. Chem. Soc.,1976
4. In vitro effect of 1-,-D-ribofuranosy1-1,2,4-triazole-3-carboxamide (Virazole, ICN 1229) on deoxyribonucleic acid and ribonucleic acid viruses;Huffman J. H.;Antimicrob. Agents Chemother.,1973
5. Potential purine antagonists. Part IV. Synthesis of N-fi-n-ribofuranosides of substituted imidazo (b) and imidazo (c) pyridines;Jain P. C.;Indian J. Chem.,1962
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