The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis-Reference-Cited by-同舟云学术

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis

Published:2018-08-15 Issue:16 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kobayashi Masatoshi¹²^ORCID,Ohsugi Mitsuru¹,Sasako Takayoshi¹,Awazawa Motoharu¹,Umehara Toshihiro¹,Iwane Aya¹,Kobayashi Naoki¹³,Okazaki Yukiko¹,Kubota Naoto¹⁴,Suzuki Ryo¹,Waki Hironori¹^ORCID,Horiuchi Keiko⁵,Hamakubo Takao⁵,Kodama Tatsuhiko⁵,Aoe Seiichiro⁶,Tobe Kazuyuki⁷,Kadowaki Takashi¹⁴,Ueki Kohjiro¹²⁴³

Affiliation:

1. Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

2. Department of Molecular Sciences on Diabetes, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

3. Department of Molecular Diabetic Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

4. Translational Systems Biology and Medicine Initiative (TSBMI), University of Tokyo, Tokyo, Japan

5. Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan

6. Department of Home Economics, Otsuma Women's University, Tokyo, Japan

7. First Department of Internal Medicine, University of Toyama, Toyama, Japan

Abstract

Adipocyte differentiation is regulated by various mechanisms, of which mitotic clonal expansion (MCE) is a key step. Although this process is known to be regulated by cell cycle modulators, the precise mechanism remains unclear.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

Japan Foundation for Applied Enzymology

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00116-18

Reference51 articles.

1. Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance