Colocalization of Chikungunya Virus with Its Receptor MXRA8 during Cell Attachment, Internalization, and Membrane Fusion

Author:

Feng Fei1,Bouma Ellen M.2,Hu Gaowei1,Zhu Yunkai1,Yu Yin1,Smit Jolanda M.2ORCID,Diamond Michael S.3456ORCID,Zhang Rong1ORCID

Affiliation:

1. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

2. Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

3. Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA

4. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA

5. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, USA

6. Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, Missouri, USA

Abstract

The globally distributed arthritogenic alphaviruses have infected millions of humans and induce rheumatic disease, such as severe polyarthralgia/polyarthritis, for weeks to years. Alphaviruses infect target cells through receptor(s) followed by clathrin-mediated endocytosis.

Funder

National Natural Science Foundation of China

Shanghai Municipal Science and Technology Major Project

STCSM | Program of Shanghai Academic Research Leader

HHS | National Institutes of Health

Graduate School of Medical Sciences of the University of Groningen

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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