Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection-Reference-Cited by-同舟云学术

Longitudinal Analysis of the Phenotype, Transcriptional Profile, and Anatomic Location of Memory CD8 T Cell Subsets after Acute Viral Infection

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gill Amanda L.¹^ORCID,Hudson William H.¹,Valanparambil Rajesh M.¹,Ahn Eunseon¹,McGuire Donald J.¹,Wieland Andreas²^ORCID,McManus Daniel T.¹,Kissick Haydn T.¹³,Akondy Rama S.⁴,Ahmed Rafi¹^ORCID

Affiliation:

1. Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

2. Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA

3. Department of Urology, Emory University School of Medicine, Atlanta, Georgia, USA

4. Trivedi School of Biosciences, Ashoka University, Sonipat, Haryana, India

Abstract

CD8 T cells play a critical role in viral immunity and it is important to understand how memory cells are formed and what processes lead to their long-term maintenance. Here, we use a mouse model of acute infection to perform an in-depth, longitudinal analysis of memory CD8 T cell differentiation, examining the phenotype and location of memory cells out to 1 year postinfection.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Achievement Rewards for College Scientists Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01556-22

Reference55 articles.

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2. Memory CD8 T-Cell Differentiation during Viral Infection

3. Origin and differentiation of human memory CD8 T cells after vaccination

4. Effector CD8 T cells dedifferentiate into long-lived memory cells

5. T CELL MEMORY

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