In a state of flux: new insight into the transport processes that maintain bacterial metal homeostasis

Author:

Kwiatos Natalia1,Waldron Kevin J.1ORCID

Affiliation:

1. Laboratory of Metalloprotein Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Abstract

ABSTRACT A new study by Nies et al. (J Bacteriol 206:e00080-24, 2024, https://doi.org/10.1128/jb.00080-24 ) provides a rich, quantitative data set of zinc accumulation by cells of Cupriavidus metallidurans , including of mutant bacterial strains lacking import or efflux genes, and comparison of zinc accumulation by cells previously starved of metal with those of zinc-replete cells. The data surprisingly demonstrate the concomitant activity of both active metal import and metal efflux systems. They present a flow equilibrium model to describe zinc homeostasis in bacteria.

Funder

Narodowe Centrum Nauki

HHS | National Institutes of Health

Publisher

American Society for Microbiology

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