Population Pharmacokinetics/Pharmacodynamics and Clinical Outcomes of Meropenem in Critically Ill Patients-Reference-Cited by-同舟云学术

Population Pharmacokinetics/Pharmacodynamics and Clinical Outcomes of Meropenem in Critically Ill Patients

Published:2022-11-15 Issue:11 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Boonpeng Apinya¹²^ORCID,Jaruratanasirikul Sutep³^ORCID,Jullangkoon Monchana³,Samaeng Maseetoh³,Wattanavijitkul Thitima⁴,Bhurayanontachai Rungsun³,Pattharachayakul Sutthiporn¹

Affiliation:

1. Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand

2. Division of Pharmaceutical Care, School of Pharmaceutical Sciences, University of Phayao, Phayao, Thailand

3. Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand

4. Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Abstract

Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill patients, thereby increasing the risk of subtherapeutic concentrations and affecting therapeutic outcomes. This study aimed to characterize the population pharmacokinetic (PPK) parameters of meropenem, evaluate the relationship between the pharmacokinetic/pharmacodynamic index of meropenem and treatment outcomes, and evaluate the different dosage regimens that can achieve 40%, 75%, and 100% of the dosing interval for which the free plasma concentrations remain above the MIC of the pathogens ( fT >MIC ) targets.

Funder

Faculty of Medicine, Prince of Songkla University

PSU | Graduate School, Prince of Songkla University

Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand

Doctor Kasem Pangsrivongse Foundation, Thailand

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00845-22

Reference37 articles.