Affiliation:
1. School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
Abstract
Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic’s MIC increases, because they are not amenable to lethal selection
in vitro
. We report that activatory mutations in the CreC signal sensor enhance growth of
Escherichia coli
in the presence of cefoxitin, cefotaxime, and meropenem, without increasing their MICs. Enhanced growth is dependent on overproduction of the inner membrane
cre
regulon protein CreD.
Funder
UK Research and Innovation | Biotechnology and Biological Sciences Research Council
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology