First Report of bla IMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131-Reference-Cited by-同舟云学术

First Report of bla IMP-14 on a Plasmid Harboring Multiple Drug Resistance Genes in Escherichia coli Sequence Type 131

Published:2016-08 Issue:8 Volume:60 Page:5068-5071
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Stoesser Nicole¹^ORCID,Sheppard Anna E.¹,Peirano Gisele²³,Sebra Robert P.⁴,Lynch Tarah³,Anson Luke W.¹,Kasarskis Andrew⁴,Motyl Mary R.⁵,Crook Derrick W.¹,Pitout Johann D.²³⁶⁷⁸

Affiliation:

1. Modernizing Medical Microbiology Consortium, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom

2. Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada

3. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

4. Icahn Institute and Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, New York, USA

5. Clinical Microbiology, Merck and Co. Inc., Rahway, New Jersey, USA

6. Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

7. Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

8. Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa

Abstract

ABSTRACT The bla IMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli , we identified a sequence type 131 strain harboring bla IMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C 2 plasmid. The emergence of bla IMP-14 in this context in the ST131 lineage is of potential clinical concern.

Funder

The Wellcome Trust

The United Kingdom Department of Health

Calgary Laboratory Services

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00840-16

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