Stimulation of Rabies Vaccine in Mice by Low Doses of Polyadenylic: Polyuridylic Complex-Reference-Cited by-同舟云学术

Stimulation of Rabies Vaccine in Mice by Low Doses of Polyadenylic: Polyuridylic Complex

Published:1972-09 Issue:3 Volume:6 Page:324-325
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Branche Robert¹,Renoux Gérard²

Affiliation:

1. Iffa-Merieux, Lyon, 69, France

2. Laboratoire d'Immunologie, Faculté de Médecine, Tours, 37, France

Abstract

Addition of 100 μg of polyadenylic: polyuridylic (poly A:U) complex to each dose of inactivated rabies vaccine increased immunity to rabies challenge in mice. Stimulation was also observed after addition of 10 μg of poly A:U to the vaccines. Mixtures of rabies vaccine and poly A:U lost their stimulatory properties after storage at 37 or 4 C for 1 month. However, these data are encouraging for practical use of poly A:U as an adjuvant to viral vaccines.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.6.3.324-325.1972

Reference5 articles.

1. Branche R. R. Lang H. G. Petermann and J. P. Soulebot. 1969. Vaccin rabique inactiv 6 produit s partir de cultures cellulaires. Resultats preliminaires p. 144-150. In R. H. Regamey (ed.) Progress in immunobiological standardization vol. 3. Karger Basel.

2. Braun W. M. Ishizuka Y. Yajima D. Webb and R. Windchruch. 1971. Spectrum and mode of action of poly A:U in the stimulation of immune response p. 139-156. In R. F. Beers and W. Braun (ed.) Biological effects of polynucleotides. Springer-Verlag Berlin.

3. Johnson A. G. R. E. Cone H. M. Friedman I. H. Han H. G. Johnson J. R. Schmidtke and R. D. Stout. 1971. Stimulation of the immune system by homopolyribonucleotides p. 157-177. In R. F. Beers and W. Braun (ed.) Biological effects of polynucleotides. Springer-Verlag Berlin.

4. World Health;Laboratory Techniques;Organ. Tech. Rep. Ser.,1954

5. A simplified method of evaluating dose-effect experiments;Litchfield J. T.;J. Pharmacol. Exp.,1949

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antigen-Antibody Reactions;Methods for General and Molecular Microbiology;2014-04-30

2. Polyclonal Antibody Production;The Biology of the Laboratory Rabbit;1994

3. Serological Methods in the Identification and Characterization of Viruses;Comprehensive Virology;1981

4. Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine;Infection and Immunity;1977-06

5. Chapter 25. Adjuvants to the Immune System;Annual Reports in Medicinal Chemistry;1974