Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis-Reference-Cited by-同舟云学术

Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis

Published:2008-01 Issue:1 Volume:15 Page:168-171
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Domínguez Jose¹²³⁴⁵,Ruiz-Manzano Juan¹²³⁴⁵,De Souza-Galvão Malú¹²³⁴⁵,Latorre Irene¹²³⁴⁵,Milà Celia¹²³⁴⁵,Blanco Silvia¹²³⁴⁵,Jiménez M. Ángeles¹²³⁴⁵,Prat Cristina¹²³⁴⁵,Lacoma Alicia¹²³⁴⁵,Altet Neus¹²³⁴⁵,Ausina Vicente¹²³⁴⁵

Affiliation:

1. Servei de Microbiologia

2. Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain

3. Universitat Autònoma de Barcelona, Bellaterra, Spain

4. Ciber Enfermedades Respiratorias, Instituto de Salud Carlos III, Badalona, Spain

5. Unidad de Prevención y Control de la Tuberculosis de Barcelona, Barcelona, Spain

Abstract

ABSTRACT We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00364-07

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