Caspofungin in Combination with Amphotericin B against Candida glabrata

Author:

Barchiesi Francesco1,Spreghini Elisabetta1,Fothergill Annette W.2,Arzeni Daniela1,Greganti Gianfranco1,Giannini Daniele3,Rinaldi Michael G.24,Scalise Giorgio1

Affiliation:

1. Istituto di Malattie Infettive e Medicina Pubblica

2. Department of Pathology, The University of Texas Health Science Center at San Antonio

3. Centro di Gestione Presidenza Medicina e Chirurgia, Università Politecnica delle Marche, Ancona, Italy

4. Audie Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas

Abstract

ABSTRACT The effects of caspofungin combined with amphotericin B were investigated with Candida glabrata . Although in vitro experiments showed an indifferent interaction, the combination regimen was the only therapeutic approach yielding organ sterilization in a murine candidemia model.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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