Affiliation:
1. Department of Microbiology, New York University School of Medicine, New York, New York
Abstract
Bernheimer, Alan
W. (New York University School of Medicine, New York),
and Lois L. Schwartz
. Lysosomal disruption by bacterial toxins. J. Bacteriol.
87:
1100–1104. 1964.—Seventeen bacterial toxins were examined for capacity (i) to disrupt rabbit leukocyte lysosomes as indicated by decrease in turbidity of lysosomal suspensions, and (ii) to alter rabbit liver lysosomes as measured by release of β-glucuronidase and acid phosphatase. Staphylococcal α-toxin,
Clostridium perfringens
α-toxin, and streptolysins O and S affected lysosomes in both systems. Staphylococcal β-toxin, leucocidin and enterotoxin, Shiga neurotoxin,
Serratia
endotoxin, diphtheria toxin, tetanus neurotoxin,
C. botulinum
type A toxin, and
C. perfringens
ε-toxin were not active in either system. Staphylococcal δ-toxin,
C. histolyticum
collagenase, crude
C. perfringens
β-toxin, and crude anthrax toxin caused lysosomal damage in only one of the test systems. There is a substantial correlation between the hemolytic property of a toxin and its capacity to disrupt lysosomes, lending support to the concept that erythrocytes and lysosomes are bounded by similar membranes.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference16 articles.
1. Lib 6ration des ferments des lysosomes par des agents enzymatiques;BEAUFAY H.;Arch. Intern. Physiol. Biochim.,1957
2. Formation of a bacterial toxin (streptolysin S) by resting cells;BERNHEIMER A. W.;J. Exptl. Med.,1949
3. Isolation and composition of staphylococcal alpha toxin;BERNHEIMER A. W.;J. Gen. Microbiol.,1963
4. The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes;COHN Z. A.;J. Exptl. Med.,1960
5. DE DUVE C. 1959. Lysosomes a new group of cytoplasmic particles p. 128-159. In T. Hayashi [ed.] Subcellular particles. Ronald Press New York.
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