Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function-Reference-Cited by-同舟云学术

Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function

Published:2020-02-14 Issue:5 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Alves-Peixoto Pedro¹²³^ORCID,Férez Maria¹,Knudson Cory J.¹,Stotesbury Colby¹,Melo-Silva Carolina R.¹,Wong Eric B.¹,Correia-Neves Margarida²³,Sigal Luis J.¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

2. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal

3. ICVS/3B’s—PT Government Associate Laboratory, Braga/Guimarães, Portugal

Abstract

Infection of adult mice with the clone 13 (CL13) strain of lymphocytic choriomeningitis virus (LCMV) is extensively used as a model of chronic infection. In this paper, we show that mice chronically infected with CL13 succumb to challenge with ectromelia virus (ECTV; the agent of mousepox) and that natural killer (NK) cells in CL13-infected mice are reduced in numbers and have an immature and partially activated phenotype but do respond to ECTV. These data may provide additional clues why humans chronically infected with certain pathogens are less resistant to viral diseases.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

MEC | Fundação para a Ciência e a Tecnologia

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01831-19

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